Coleonol or Forskolin is a chemical found in the roots of Coleus forskohlii, an Indian Coleus plant. It was first analyzed in 1974 by scientists from Central Drug Research Institute of India and Hoechst India in screening systems that examined medicative plants mostly for cardiovascular activity. Aside from being used to increase cyclic AMP (cAMP) levels in study and research of cell philosophy, Forskolin has been used since ancient times to treat high blood pressure, heart disorders and angina and at times respiratory disorders like asthma. Coming back to cell research, Coleonol activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP thus re-sensitizing cell receptors.
A signal carrier is needed for better responsiveness between cells to hormones and also other extracellular signals. cAMP is the signal carrier. Hormones’ feedback control and cell communication in hypothalamus/pituitary gland axis is possible due to cAMP as it activates protein kinase A. In the field of healthcare, Forskolin, when taken by mouth can be used to treat allergies and other skin conditions like psoriasis and eczema. This page has more in-depth material on forskolin. Other medical conditions treated are irritable bowel syndrome, obesity, menstrual difficulties, bladder infections, urinary tract infections, blood clots, insomnia, convulsions, sexual difficulties in men, and also advanced cases of cancer. Forskolin can additionally be applied intravenously during heart failure. Forskolin powder is said to be quite effective for asthma.
Glaucoma has been treated with Forskolin drops. Infusions from Coleus forskohlii are used by herbal product makers also and being boosted to spread knowledge about its use though conclusive, reliable scientific information carrying on the medical advantages of Forskolin (when taken by mouth) are not currently accessible. Lots of research is presently being undertaken globally. Forskolin produces strong heartbeat and widens blood vessels thereby lowering blood pressure. It works on the heart muscles and walls of blood vessels. It acts as a vasodilator. One can find the drug over the counter in liquid form or as pills. Dosages vary depending on the medical condition. Most commonly employed dosages are – 125mg coleus forskohlii herbal infusion offering 12.5mg of Forskolin and 50mg coleus forskohlii herbal infusion offering 9mg of Forskolin. Research is restricted to the dosages for different states.
0.2%-0.3% is commonly the Forskolin content in coleus root. So, it can be viewed the Forskolin content in crude coleus products may not be sufficient for treating complex medical conditions as they might not create the desired pharmacological effect. Concentrated Forskolin as discovered in standardized products are best to use where various infusion potencies of Coleus forskohlii like the 10% Forskolin, 18% Forskolin and 20% Forskolin are available. For a deeper understanding of forskolin, visit this webpage. Yet, all the potencies never have yet been analyzed; thus it’s impossible to say which potency is best to use.